Jae Yeon Joo
BME PhD Proposal Presentation
Date: 2024-11-06
Time: 10:30-12:00
Location / Meeting Link: HSRB I E160 / Zoom: https://gatech.zoom.us/j/92965996864
Committee Members:
Philip J. Santangelo, PhD (Advisor); James E. Dahlman, PhD; Karmella A. Haynes, PhD; David R. Myers, PhD; Francois Villinger, DVM, PhD
Title: Development of mRNA-encoded Antibodies for HIV Prevention and Contraception via Intravaginal Delivery: Advancing Women’s Reproductive Health
Abstract:
Many women are at risk of HIV transmission and unintended pregnancies. While existing prevention methods, such as condoms and hormonal contraceptives, have proven effective, their consistent use is often compromised by issues related to user satisfaction and adherence, which ultimately reduces their effectiveness. This project addresses the current challenges in women’s reproductive health by focusing on preventing both HIV transmission and unintended pregnancies. We propose to develop mRNA-encoded antibodies for intravaginal delivery, providing localized and dual prevention against these concerns. The proposal consists of three main objectives. In Aim 1, we will focus on developing and optimizing mRNA-encoded broadly neutralizing antibodies (bnAbs) against HIV via intravaginal delivery, ensuring localized protection at the primary site of transmission. In Aim 2, we will investigate the co-expression of mRNA-encoded antibodies that target both HIV and human sperm, thereby providing comprehensive protection through a single delivery platform. In Aim 3, we will optimize mRNA intravaginal delivery and evaluate in vivo efficacy in animal models, assessing their prevention efficacy and safety profiles. This research has the potential to advance women’s reproductive health by providing a safer, more effective, and accessible dual-protection solution for HIV prevention and contraception. Additionally, the findings from this study may extend to the prevention of other sexually transmitted infections, addressing current unmet needs in women’s reproductive health.